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Laurie's fame expanded to the American public in 2004, when he first starred as the acerbic physician specialising in diagnostic medicine, Dr Gregory House in the popular Fox medical drama House.

For his portrayal, Laurie assumes an American accent.

Laurie was in Namibia filming Flight of the Phoenix and recorded the audition tape for the show in the bathroom of the hotel, the only place he could get enough light.

While working on Flight of the Phoenix, Jacob Vargas operated the camera to shoot Laurie's audition tape for House.

Laurie's American accent was so convincing that executive producer Bryan Singer, who was unaware at the time that Laurie is British, pointed to him as an example of just the kind of compelling American actor he had been looking for.

Laurie also adopts the accent between takes on the set of House, as well as during script read-throughs, although he used his native accent when directing the House episode " Lockdown ".