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By far, the most common cause of severe hypoglycemia in this age range is insulin injected for type 1 diabetes.
Circumstances should provide clues fairly quickly for the new diseases causing severe hypoglycemia.
All of the congenital metabolic defects, congenital forms of hyperinsulinism, and congenital hypopituitarism are likely to have already been diagnosed or are unlikely to start causing new hypoglycemia at this age.
Body mass is large enough to make starvation hypoglycemia and idiopathic ketotic hypoglycemia quite uncommon.
Recurrent mild hypoglycemia may fit a reactive hypoglycemia pattern, but this is also the peak age for idiopathic postprandial syndrome, and recurrent " spells " in this age group can be traced to orthostatic hypotension or hyperventilation as often as demonstrable hypoglycemia.

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