Page "Immunosuppressive drug" Paragraph 54

Mycophenolic acid acts as a non-competitive, selective, and reversible inhibitor of Inosine-5 ′- monophosphate dehydrogenase ( IMPDH ), which is a key enzyme in the de novo guanosine nucleotide synthesis.

In contrast to other human cell types, lymphocytes B and T are very dependent on this process.