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The Indian historian D. P.
Agrawal suggests that the practice originated in India.
A religious rite having this effect was attributed to the physician Dhanvantari, founder of the Vedic tradition, in about 1500 BCE.
As with other medical customs, the inoculation was associated with a Hindu goddess.
This ancient inoculation procedure featured in the BBC documentary-What the Ancients Did for Us.
In the 18th century Dr. J. Z.
Holwell wrote the most detailed account for the college of Physicians in London, describing not only inoculation, but also showing that the Indians knew that microbes caused such diseases:

1.926 seconds.