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Itanium failed to make significant inroads against IA-32 or RISC, and then suffered from the successful introduction of x86-64 based systems into the high-end server market, systems which were more compatible with the older x86 applications.

Journalist John C. Dvorak, commenting in 2009 on the history of the Itanium processor, said " This continues to be one of the great fiascos of the last 50 years " in an article titled " How the Itanium Killed the Computer Industry ".

Tech columnist Ashlee Vance commented that the delays and underperformance " turned the product into a joke in the chip industry.

" In an interview, Donald Knuth said " The Itanium approach ... was supposed to be so terrific — until it turned out that the wished-for compilers were basically impossible to write.