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As part of the world-wide expansion of Stirling and Wilford's practice beginning in the 1970s, the firm completed four significant buildings in the U. S., all university structures that exhibit inventive responses to their existing campus settings: an addition for the Rice University School of Architecture in Houston, Texas ; the Arthur M. Sackler Museum at Harvard University in Cambridge, Massachusetts ; the Schwartz Center for the Performing Arts at Cornell University in Ithaca, New York ; and the Biological Sciences Library at the University of California, Irvine.

Among unrealized projects in the US are designs for Columbia University and a competition proposal for the Walt Disney Concert Hall in Los Angeles.