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Alexander is best known as one of the key cast members of the award-winning television sitcom Seinfeld ( 1989 – 1998 ), in which he played George Costanza ( Jerry Seinfeld's character's best friend since childhood ).

Before Seinfeld, he starred in a short-lived CBS sitcom called Everything's Relative in 1987 which lasted six episodes.

Concurrently with his Seinfeld role, Alexander provided the voice of the lead character in the cult animated series Duckman ( 1994 – 1997 ).

Alexander also voiced Catbert, the evil director of human resources, in the short-lived Dilbert animated series based on the popular comic strip.

He made cameo appearances in the second season of Curb Your Enthusiasm, playing himself.

Alexander also appeared in the seventh season of Curb Your Enthusiasm, along with the other three principal Seinfeld cast members.

He also had a part in the ABC sitcom Dinosaurs, as Al " Sexual " Harris ( who frequently engaged in sexual harassment ).

Despite a relatively successful career in film and stage, Alexander never managed to repeat his Seinfeld-level of success in television.

2001 marked his first post-Seinfeld return to prime-time television: the heavily promoted but short-lived ABC sitcom Bob Patterson ( which was canceled after just 5 episodes ).

Alexander partially blames the lack of success on the mood of the country after 9 / 11.

His second chance as a TV series lead, the CBS sitcom Listen Up!

( September 20, 2004 to April 25, 2005 ), also fell short of a second season.

Alexander was also the principal executive producer of the series based very loosely on the life of the popular sports-media personality Tony Kornheiser.

Alexander appeared on the Family Guy: Live in Vegas CD singing a verse in the song " All Cartoons are Fuckin ' Dicks ".

He was featured in the Friends episode " The One Where Rosita Dies " as a suicidal supply manager named Earl.

Phoebe calls him trying to sell him toner and she learns about his problem and tries to persuade him not to commit suicide.

This is referred to in an episode of Malcolm in the Middle where Alexander appears as a neurotic and critical loner called Leonard.

He describes himself as free and mentions that he makes money with a job " selling toner over the phone ".

Also in the episode, he is repeatedly harassed by a man named George – his character's name on Seinfeld.

Alexander appeared in the 1995 TV version of the Broadway musical Bye Bye Birdie, as Conrad Birdie's agent, Albert Peterson.

He guest-starred in episode 8 of the 1996 variety show Muppets Tonight.

Alexander appeared on Star Trek: Voyager on the episode " Think Tank " playing a genius alien named Kurros who was trying to get Seven of Nine to serve on his ship.

He appeared in the first episode of the short-lived 2002 revival of The Twilight Zone, playing Death.

He featured in the 2005 Monk episode " Mr. Monk and the Other Detective " as Monk's rival, Marty Eels.

On the June 26, 2006 episode of the Jimmy Kimmel Live!