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In the first weeks of 1336 Ashikaga Takauji left Kamakura for Kyoto in pursuit of Nitta Yoshisada.
He left behind his 4-year-old son Yoshiakira as his representative in the trust of three guardians: Hosokawa Kiyouji, Uesugi Noriaki, and Shiba Ienaga.
In 1349 Takauji called Yoshiakira to Kyoto, replacing him with another of his sons, Motouji, to whom he gave the title of Kantō Kanrei.
Because the kanrei was the son of the shogun, ruled Kantō and controlled the military there, the area was usually called Kamakura Bakufu, or Kamakura Shogunate, and Motouji Shogun or Kamakura / Kantō Gosho, an equivalent title.
When later the habit of calling kubō the shogun spread from Kyoto to the Kantō, the ruler of Kamakura came to be called Kamakura kubō.
The Kanrei title was then passed on to the Uesugi hereditary.
Members of the Uesugi family thereafter dominated the Kantō kanrei post until 1552, when it was abolished.

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