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La Voisin resided at Villeneuve-sur-Gravois, where she received her clients.
She tended to her clients all day, and entertained at parties with violin music in her gardens at night, attended by Parisian upper class society.
The house also included a furnace for the bodies of dead babies, who were then buried in the garden.
She regularly attended at the services at the church of the Jansenist abbé de Sant-Amour, principal at the Paris University, and godmother of her daughter was the noblewoman de la Roche-Guyon.
She supported a family of six, including her mother, and among her lovers were the executioner Andre Guillaume, Latour, vicomte de Cousserans, count de Labatie, the alchemist Blessis, the architect Fauchet and the magician Adam Lesage.
At one point, Adam Lesage tried to induce her to kill her husband, but she regretted the plan and aborted the process.
La Voisin was interested in science and alchemy and financed several private projects and enterprises, some of them made by con artists who tried to fool money out of her.
Privately, she suffered from alcoholism, was apparently abused by Latour, and engaged in severe conflicts with her rival, poisoner Marie Bosse.

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