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Lampanelli released a comedy special on DVD entitled Take it Like A Man in 2005, appeared in the 2006 motion picture Larry the Cable Guy: Health Inspector, and had a cameo appearance in the VH1 sitcom So NoTORIous.

She also landed a deal with Fox for a sitcom pilot with the tentative title Big Loud Lisa, which was considered a candidate for the network's 2006 – 07 television season.

Lampanelli taped her stand-up special Dirty Girl in the fall of 2006, which aired on Comedy Central on January 28, 2007.

Her Dirty Girl CD and Dirty Girl .. No Protection DVD were released by Warner Bros ./ Jack Records on January 30, 2007.

Lampanelli was also featured in the movie Delta Farce starring Larry the Cable Guy, Bill Engvall and D. J.

Qualls, which was released early in 2007, and in Drillbit Taylor starring Owen Wilson.