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At eight years old, Lisa is the second child of Homer and Marge, younger sister of Bart and older sister of Maggie.

She is highly intelligent and plays the baritone saxophone.

She has been a vegetarian since season 7, converted to Buddhism in season 13 and advocates for a variety of political causes, including the Tibetan independence movement.

She has appeared in other media relating to The Simpsons – including video games, The Simpsons Movie, The Simpsons Ride, commercials and comic books – and inspired a line of merchandise.