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In the episode " The Uncanny Valley ", the unsub Samantha Malcolm induces locked-in syndrome using a series of drugs in three women.
Her reason is she is trying to complete a series of dolls she lost as a young girl.
Every two months, a woman will die as the stress wreaks havoc on the body.
Only one woman, who has diabetes, is able to counteract the drugs and fight off her locked-in syndrome.

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