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His engagement for the Lowell Institute lectures precipitated the establishment of the Lawrence Scientific School at Harvard University in 1847 with him as its head.
Harvard appointed him professor of zoology and geology, and he founded the Museum of Comparative Zoology there in 1859 serving as the museum's first director until his death in 1873.
During his tenure at Harvard, he was, among many other things, an early student of the effect of the last Ice Age on North America.

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