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Negotiations for a marriage between Manuel and Elizabeth of York in 1485 were halted by the death of Richard III of England.
He went on to marry three times.
His first wife was Isabella of Aragon, princess of Spain and widow of the previous Prince of Portugal Afonso.
Next he married another princess of Spain, Maria of Aragon ( his first wife's sister ), then Eleanor of Austria, a niece of his first two wives who married Francis I of France after Manuel's death.

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