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Toward the end of season one, Matlock also took on Cassie Phillips, a cocky young lawyer played by Kari Lizer, as an assistant.

After the season was over, Linda Purl departed from the series due to disputes regarding her character and her castmates and Charlene was written out of the series by having moved to Philadelphia to start her own law practice.

To begin the season, Matlock went over to England to try a case and met Michelle Thomas, an American lawyer living in London played by Nancy Stafford, while doing so.

After the case was over, Michelle followed Matlock back to the United States and took over Charlene's role as partner.

Cassie stayed on as file clerk until the end of the second season, when she disappeared for reasons never made clear.

With Lizer's departure Julie Sommars became a regular cast member.