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At the 38th Grammy Awards, in 1996, Me Against the World was nominated for Best Rap Album and the single " Dear Mama " was nominated for Best Rap Solo Performance.

In 2008, the National Association of Recording Merchandisers, in conjunction with the Rock and Roll Hall of Fame, recognized Me Against the World as one of the " most influential and popular albums ", ranking it number 170 on a list of 200 other albums by artists of various musical genres.