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It is also possible to vary the discipline: In Dune, the Tleilaxu create " twisted Mentats " for Baron Vladimir Harkonnen ( Piter De Vries being the most notable example ).
These are sociopathic Mentats free from the usual constraints of human morality or instinctual considerations ( Piter is, among other things, a sadist, and acts as torturer for the Baron ).
In Heretics of Dune the Tleilaxu supply the Bene Gesserit with a Duncan ghola they have altered in many subtle and hidden ways, including the addition of submerged Mentat abilities.

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