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All opioids have tiredness as a major side effect, which can lead to the patient being in an almost half-awake state, in medical terms known as sedation.
Many patients report that Methadone's sedation effect is often less pronounced than with other opioids and cite this as a major argument for preferring Methadone as an analgesic .< ref > Persons reciveing MMT should not suffer from extreme sedation as a resullt of the treatment, due to the fact that a properly prescribed person will have had their dose titrated up to the optimal level to remove the effects of withdrawl, a point at which sedation should not be evident.

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