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* ( 5 ) Cystathionine-β-synthase ( a PLP-dependent enzyme ) combines homocysteine and serine to produce cystathionine.
Instead of degrading cystathionine via cystathionine-β-lyase, as in the biosynthetic pathway, cystathionine is broken down to cysteine and α-ketobutyrate via ( 6 ) cystathionine-γ-lyase.

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