Page "Microglia" Paragraph 54

One way to control neuroinflammation is to inhibit microglial activation.

Studies on microglia have shown that they are activated by diverse stimuli but they are dependent on activation of mitogen-activated protein kinase ( MAPK ).

Previous approaches to down-regulate activated microglia focused on immunosuppressants.

Recently, minocycline ( a tetracycline derivative ) has shown down-regulation of microglial MAPK.

Another promising treatment is CPI-1189, which induces cell death in a TNF α-inhibiting compound that also down-regulates MAPK.

Recent study shows that nicergoline ( Sermion ) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia.