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Space sickness was effectively unknown during the earliest spaceflights, as these were undertaken in very cramped conditions ; it seems to be aggravated by being able to freely move around, and so is more common in larger spacecraft.
Around 60 % of Space Shuttle astronauts currently experience it on their first flight ; the first case is now suspected to be Gherman Titov, in August 1961 onboard Vostok 2, who reported dizziness and nausea.
However, the first significant cases were in early Apollo flights ; Frank Borman on Apollo 8 and Rusty Schweickart on Apollo 9.
Both experienced identifiable and reasonably severe symptoms — in the latter case causing the mission plan to be modified.

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