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The most challenging case is when the delay and Doppler spreads are both large, i. e., the coherence bandwidth and coherence time are both small.
A short coherence time limits the symbol time, or more precisely, the maximum coherent detection interval at the receiver.
If the symbol energy is too small for an adequate per-symbol detection SNR, then one alternative is transmit a symbol longer than the coherence time but to detect it with a filter much
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