Page "Muscadine" Paragraph 41

In a randomized, double-blind, placebo-controlled crossover trial, 50 adults with coronary disease or ≥ 1 cardiac risk factor received muscadine grape seed supplementation ( 1300 mg daily ) and placebo for 4 weeks.

There was no statistically significant increase in brachial flow-mediated vasodilation or a significant change in other biomarkers of inflammation, lipid peroxidation, or antioxidant capacity.

However there was a significant increase in resting brachial artery diameter.

The clinical significance of this is not clear.