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The interpretation of nerve conduction studies is complex, but, in general, different pathological processes result in changes in latencies, motor, and / or sensory amplitudes, or slowing of the conduction velocities to differing degrees.
For example, slowing of the NCV usually indicates there is damage to the myelin.
Another example, slowing across the wrist for the motor and sensory latencies of the median nerve indicates focal compression of the median nerve at the wrist, called carpal tunnel syndrome.
On the other hand, slowing of all nerve conductions in more than one limb indicates generalized diseased nerves, or generalized peripheral neuropathy.
People with diabetes mellitus often develop generalized peripheral neuropathy.

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