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This low-level crossing of the Appalachians, many millions of years old, has long been a biogeograpical corridor allowing numerous species of plants and animals to spread between the lowlands of the American East Coast and those of the Midwest ; other unusual kinds of plants occur on the gorge's cliffs or rim-top ledges.
Portions of this corridor are now also used by various railroads and highways, and some segments of the river have been dammed for hydroelectric power production.

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