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There is anecdotal evidence that the use of nitrox reduces post-dive fatigue, particularly in older and or obese divers ; however a double-blind study to test this found no statistically significant reduction in reported fatigue.
There was, however, some suggestion that post dive fatigue is due to sub-clinical decompression sickness ( DCS ) ( i. e. micro bubbles in the blood insufficient to cause symptoms of DCS ); the fact that the study mentioned was conducted in a dry chamber with an ideal decompression profile may have been sufficient to reduce sub-clinical DCS and prevent fatigue in both nitrox and air divers.
In 2008, a study was published using wet divers at the same depth and confirmed that no statistically significant reduction in reported fatigue is seen.

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