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After the war's conclusion, Holmes returned to Harvard to study law.
He was admitted to the bar in 1866, and went into practice in Boston.
He joined a small firm, and married a childhood friend, Fanny Bowditch Dixwell.
Their marriage lasted until her death on April 30, 1929.
They never had children together.
They did adopt and raise an orphaned cousin, Dorothy Upham.
Mrs. Holmes was described as devoted, witty, wise, tactful, and perceptive.

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