Page "Oxime" Paragraph 10

Generally oximes can be changed to the corresponding amide derivatives by treatment with various acids.

This reaction is called Beckmann rearrangement.

In this reaction, a hydroxyl group is exchanged with the group that is in the anti position of the hydroxyl group.

The amide derivatives that are obtained by Beckmann rearrangement can be transformed into a carboxylic acid by means of hydrolysis ( base or acid catalyzed ). And an amine by hoffman degradation of the amide in the presence of alkali hypoclorites at 80 degrees Celsius, the degradation is itself prone to side reactions namely, the formation of biurets or, cyanate polymers, To avoid this side reaction strict temperature control is necessary, the reaction must be conducted at sufficient temperature to isomerise the cyanate to the isocyante.