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This transfer of loyalties of the oldest brother and head of the whole family, Diego, after Henry's death in December 1474, was duly rewarded by Queen Isabella I of Castile, Queen successor since December 1474 awarding Diego the title of Duke of the Infantado or Duke of l ' Infantado on 22 July 1475.
The title would be awarded the Grandee of Spain in 1519 by king Charles I of Spain, a. k. a. Holy Roman Emperor Charles V.

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