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Science relies on evidence to validate its theories and models, and the predictions implied by those theories and models should be in agreement with observation.
Ultimately, observations reduce to those made by the unaided human senses: sight, hearing, etc.
To be accepted by most scientists, several impartial, competent observers should agree on what is observed.
Observations should be repeatable, e. g., experiments that generate relevant observations can be ( and, if important, usually will be ) done again.
Furthermore, predictions should be specific ; one should be able to describe a possible observation that would falsify the theory or a model that implies the prediction.

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