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Some types of phospholipid can be split to produce products that function as second messengers in signal transduction.
Examples include phosphatidylinositol ( 4, 5 )- bisphosphate ( PIP < sub > 2 </ sub >), that can be split by the enzyme Phospholipase C into inositol triphosphate ( IP < sub > 3 </ sub >) and diacylglycerol ( DAG ), which both carry out the functions of the G < sub > q </ sub > type of G protein in response to various stimuli and intervene in various processes from long term depression in neurons < ref > to leukocyte signal pathways started by chemokine receptors .< ref >

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