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He went to Rome during the pontificate of Pope Urban VIII ( 1623 – 44 ), and was made governor of Terni, Rieti, and Spoleto.
For fourteen years he served as auditor of the Rota.
At the request of the Venetian Republic, Ottoboni was made Cardinal-Priest of San Salvatore in Lauro by Pope Innocent X ( 1644 – 55 ) in 1652, and was later given the bishopric of Brescia, in Venetian territory, where he quietly spent the best years of middle life.

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