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Innocent VIII died on 25 July 1492 leaving behind him two illegitimate children born before he entered the clergy.
Another source says " sixteen ", the remaining fourteen of which were presented as nephews.
The title Padre della patria (= Father of the Fatherland ) was suggested for him, precisely with reference to these sixteen children of his.
In 1487 he married his elder son Franceschetto Cybo ( d. 1519 ) to Maddalena de ' Medici ( 1473 – 1528 ), the natural daughter of Lorenzo de ' Medici, who in return obtained the cardinal's hat for his thirteen-year-old son Giovanni, later Pope Leo X.
His daughter Teodorina Cybo married Gerardo Usodimare and had a daughter.
Savonarola chastised him for his worldly ambitions.
The unsympathetic Roman chronicler Stefano Infessura provides many lively details, among them the apparent attempt to revive Innocent VIII on his deathbed by blood transfusions from three young male children ( who died as well in the process ).

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