Page "Protein engineering" Paragraph 4
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In directed evolution, random mutagenesis is applied to a protein, and a selection regime is used to pick out variants that have the desired qualities.
This method mimics natural evolution and generally produces superior results to rational design. An additional technique known as DNA shuffling mixes and matches pieces of successful variants in order to produce better results.
The great advantage of directed evolution is that it requires no prior structural knowledge of a protein, nor is it necessary to be able to predict what effect a given mutation will have.
Indeed, the results of directed evolution experiments are often surprising in that desired changes are often caused by mutations that were not expected to have that effect.
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