Page "Protein targeting" Paragraph 2

In 1970, Günter Blobel conducted experiments on the translocation of proteins across membranes.

He was awarded the 1999 Nobel prize for his findings.

He discovered that many proteins have a signal sequence, that is, a short amino acid sequence at one end that functions like a postal code for the target organelle.

The translation of mRNA into protein by a ribosome takes place within the cytosol.

If the synthesized proteins " belong " in a different organelle, they can be transported there in either of two ways depending on the protein: Cotranslational translocation ( translocation during the process of translation ), and Posttranslational translocation ( translocation after the process of translation is complete ).