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As with The Quatermass Xperiment, the screenplay for Quatermass 2 condenses many of the events of the original.
The most significant change is at the climax: in the television version Quatermass and his assistant, Pugh, use Quatermass ' rocket to travel to the asteroid to take on the aliens on their home turf whereas in the film the rocket is fired, unmanned, at the asteroid to destroy it.
Several characters from the television version do not appear in the film, most notably Quatermass ' daughter, Paula, and his assistant, Leo Pugh.
Conversely, the character of Inspector Lomax reappears in the film version, having previously been in The Quatermass Xperiment, but does not appear in the television version.
The character of Sheila the barmaid also appears only in the film version.

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