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Crist was a graduate of the former Messiah School ( 1916 ), now known as Messiah College, Dickinson College ( B. A., 1920 ) and Columbia University ( Ph. D., 1925 ).
Crist joined the faculty at Columbia University where he was a teacher and researcher from 1925 to 1941.
He joined the Manhattan Project in 1941 and was among the leading scientists who developed the critical initial step of the separation of uranium isotopes.
He was director of the Manhattan Project, Columbia University Group, 1945-6, after which he joined the Union Carbide Corporation in Charleston, West Virginia, first as Manager of the Coal Hydrogenation Plant, and then as Director of Research of the Olefins Division.

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