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In 1475 he went to Rome to work with Pope Sixtus IV on calendar reform.
Regiomontanus died of unknown causes in Rome, July 6, 1476, a month after his fortieth birthday.
According to a rumor repeated by Gassendi in his Regiomontanus biography he was assassinated by relatives of George of Trebizond whom he had criticized in his writings.
More likely he died in an epidemic raging in Rome at the time.

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