Page "Rett syndrome" Paragraph 42

Signs may stabilize for many decades, particularly for interaction and cognitive function such as making choices.

Asocial behavior may change to highly social behavior.

Motor functions may slow as rigidity and dystonia appear.

Seizures may be problematic, with a wide range of severity.

Scoliosis occurs in most, and may require corrective surgery.

Those who remain ambulatory tend to have less progression of scoliosis.