Page "Reverse transcriptase" Paragraph 29

Reverse transcriptase has a high error rate when transcribing RNA into DNA since, unlike any other DNA polymerases, it has no proofreading ability.

This high error rate allows mutations to accumulate at an accelerated rate relative to proofread forms of replication.

The commercially available reverse transcriptases produced by Promega are quoted by their manuals as having error rates in the range of 1 in 17, 000 bases for AMV and 1 in 30, 000 bases for M-MLV