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Stickgold was born in Chicago.
He graduated from Harvard University before attending the University of Wisconsin – Madison where he received his doctorate in biochemistry.
He worked with the prominent sleep researcher J. Allan Hobson for many years.
Stickgold's research has focused on sleep and cognition, dreaming, and conscious states.
He has been a major proponent of the role of sleep in memory consolidation.
Additional research has focused on dreaming.
In one experiment, participants played the computer game Tetris for three days and reported dreaming about falling geometric shapes.
Even patients with anterograde amnesia, who did not remember playing the game, had similar dreams as normal participants.
Similar results were found in another study utilizing the video game Alpine Racer 2.
Participants reported dreaming about skiing.

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