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Although commonly used in a colloquial and less-violent sense, the phrase is particularly associated with a specific sociopathic culture-bound syndrome in Malaysian culture.
In a typical case of running amok, a male who has shown no previous sign of anger or any inclination to violence will acquire a weapon, traditionally a sword or dagger, but presently a variety of weapons are used, and in a sudden frenzy, will attempt to kill or seriously injure anyone he encounters.
Amok typically takes place in a well populated or crowded area.
Amok episodes of this kind normally end with the attacker being killed by bystanders or committing suicide, eliciting theories that amok may be a form of intentional suicide in cultures where suicide is heavily stigmatized.
Those who do not commit suicide and are not killed typically lose consciousness, and upon regaining consciousness, claim amnesia.

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