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The series served as a stepping stone for some of Hollywood's most notable actors, including Leonard Nimoy, Robert Conrad, Bruce Dern, Ron Foster, Larry Hagman, Ross Martin, Daria Massey, Jack Nicholson ( in the last episode of the series ), and Bridges ' own sons, Beau and Jeff.

Russ Conway guest-starred eight times on the series.

Many lesser-known actors also appeared, such as Peter Breck, Robert Karnes, Tyler McVey, Gregg Palmer, Alvaro Guillot and Paul Stader.