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A revival would begin when Seleucus II's younger son, Antiochus III the Great, took the throne in 223 BC.
Although initially unsuccessful in the Fourth Syrian War against Egypt, which led to a defeat at the Battle of Raphia ( 217 BC ), Antiochus would prove himself to be the greatest of the Seleucid rulers after Seleucus I himself.
He spent the next ten years on his anabasis through the eastern parts of his domain and restoring rebellious vassals like Parthia and Greco-Bactria to at least nominal obedience.
He won the Battle of the Arius and besieged the Bactrian capital, and even emulated Alexander with an expedition into India where he met with king Sophagasenus receiving war elephants:

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