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The term, which was spelled semeiotics, derives from the Greek σημειωτικός, ( sēmeiōtikos ), " observant of signs " ( from σημεῖον-sēmeion, " a sign, a mark ") and it was first used in English by Henry Stubbes in a very precise sense to denote the branch of medical science relating to the interpretation of signs.
John Locke used the terms semeiotike and semeiotics in Book 4, Chapter 21 of An Essay Concerning Human Understanding ( 1690 ).
Here he explains how science can be divided into three parts:

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