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In 2011 Stuart Semple was made an Ambassador for mental health charity Mind and is initiating a Creative Therapies fund within the organization.

Semple also supported MTV's Re: Define exhibition at The Goss-Michael Foundation in 2011 with auction proceeds donated to MTV Staying Alive Foundation which enables inspirational youngsters to fight HIV and AIDS in their local communities.

He has also supported the Africa Foundation via Art for Africa with Sotheby's, Macmillan De ' Longhi Art Auction at Bonhams and the medical foundation Freedom From Torture's art auction.

In 2011 Semple was featured on postcards for the Anaphylaxis campaign and created artworks for the Freedom of Expression Campaign for Amnesty International.