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After his breakout role in The Silence of the Lambs ( as primary antagonist Buffalo Bill ), there was a period where he was typecast in villainous roles.
Levine was able to remedy this by playing more positive characters, such as a member of Al Pacino's police unit in Heat, astronaut Alan Shepard in the HBO mini-series From the Earth to the Moon, and Paul Walker's police superior Sergeant Tanner in The Fast and the Furious.
In the drama Georgia, he played Mare Winningham's husband, one of his most sympathetic roles.
His résumé also includes an uncredited role as the voice of the sociopathic trucker " Rusty Nail " in 2001's Joy Ride, and his performance as Detective Sam Nico in the 2003 film Wonderland, based on the gruesome murders in the Hollywood Hills.
From 2002 to 2009, he co-starred as Captain Leland Stottlemeyer on USA Network's detective series Monk, starring Tony Shalhoub.

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