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At Bristol, one of his teachers was Rendle Short, who had proposed that appendicitis is caused by a lack of cellulose in the diet ( it is worth noting, perhaps, from a biographical perspective, that Cleave's sister had died at the age of eight years from a perforated appendicitis ).
Charles Darwin's writings provided the intellectual framework to Cleave's lifelong engagement with the relationship between diet and health, built upon the premise that the human body is ill-adapted to the diet of modern ( western ) man.

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