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A defining feature of transcription factors is that they contain one or more DNA-binding domains ( DBDs ), which attach to specific sequences of DNA adjacent to the genes that they regulate.
Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA-binding domains, and, therefore, are not classified as transcription factors.

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