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The city of Trikala is built on the ancient city Trikka or Trikke, which was founded around the 3rd millennium B. C.
and took its name by the nymph Trikke, daughter of Penaeus, or according to others, daughter of Asopus river.
The city was an important center in Antiquity as the birthplace and main residence of Asclepius.
In the region existed indeed one of the most important and ancient asclepieia.
The city is mentioned in Homer's Iliad as having participated in the Trojan War with thirty ships under Asclepius ' sons Machaon and Podalirius.
In the Mycenean period, the city was the capital of a kingdom, and later it constituted the main center of the Thessalian region of Estaiotis, which occupied roughly the territory of the modern Trikala Prefecture.

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